Research In The Area Of Non-Small Cell Lung Cancer Risk Factors Reported From Cancer Institute

25.08.2008 at 08:00 - Category: Cancer and Oncology

Researchers detail in 'Influence of smoking on histologic type and the efficacy of adjuvant chemotherapy in resected non-small cell lung cancer,' new data in non-small cell lung cancer. "Numerous studies indicate that smoking is associated with many factors that contribute to poorer outcomes in patients with lung cancer and may limit the efficacy of treatment, especially in advanced non-small cell lung cancer (NSCLC), but little is known about its effect on treatment of resected NSCLC. The aim of this study was to determine the impact of smoking on adjuvant chemotherapy in patients with NSCLC," scientists in People's Republic of China report.

"Another objective of our study was to investigate the relationship between smoking status and the clinical characteristics of patients with NSCLC. A sretrospective analysis was carried out on patients with NSCLC seen during the period January 1990 until December 2000. Clinical characteristics and survival outcomes were reviewed and compared between patients with different smoking status. Of 1270 patients who were eligible for analysis, 319 received adjuvant chemotherapy. Sex, age, tumor location, tumor size, symptoms including hemoptysis, cough, blood in sputum and histologic types were different between smokers and non-smokers. Patients with PY >22.75 were more likely to have squamous cell lung cancer. In non-smokers and patients with PY 10, adjuvant chemotherapy did not have a survival benefit. A patient with PY >22.75 is more likely to develop squamous cell lung cancer," wrote Z. Zhang and colleagues, Cancer Institute.

The researchers concluded: "In non-smokers and patients with PY or, adjuvant chemotherapy has a survival benefit."

Zhang and colleagues published their study in Lung Cancer (Influence of smoking on histologic type and the efficacy of adjuvant chemotherapy in resected non-small cell lung cancer. Lung Cancer, 2008;60(3):434-40).

For additional information, contact Z. Zhang, Cancer Institute & Hospital, Dept. of Lung cancer, Tian Jin Medical University, Tian Jin, PR China.

The publisher's contact information for the journal Lung Cancer is: Elsevier Science Ireland Ltd., Customer Relations Manager, Bay 15, Shannon Industrial Estate, Co. Clare, Ireland.

Original text is here

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Research In The Area Of Non-Small Cell Lung Cancer Risk Factors Reported From Cancer Institute