30.08.2008 at 08:00
- Category:
Cancer and Oncology
Few studies have looked at the link between sex hormones in the blood and cancer recurrence. Cheryl L. Rock, Ph.D., a professor in the Department of Family and Preventive Medicine at the University of California in San Diego, reported that women whose breast cancer came back after treatment had almost twice as much estrogen in their blood than did women who remained cancer-free-despite treatment with anti-estrogen drugs in most of the women.
Their findings suggested that high levels of estrogen contributed to an increased risk of cancer recurrence, just as they lead to the initial development of breast cancer. Participants from this study were drawn from the larger Women's Healthy Eating and Living Study (WHEL), a dietary intervention trial that followed 3,088 women who had been treated for early-stage breast cancer but who were cancer-free when they enrolled.
Participants were randomly assigned to one of two groups. One group ate a normal healthy diet, and the other that ate extremely high amounts of fruits, fiber, and vegetables. The participants were observed for more than seven years. Breast cancer recurrence was about the same in each group. Two-thirds of the participants were using tamoxifen (Nolvadex®). When they enrolled, their blood was tested for concentrations of the steroid hormones estradiol (the primary human estrogen) and testosterone. The researchers analyzed different forms of estradiol and testosterone in the blood.
Researchers found that higher estradiol concentrations, in all forms, significantly predicted cancer recurrence. Overall, women whose cancer returned had an average total estradiol concentration that was more than double the average for women who remained free of cancer. Increased testosterone levels were not associated with recurrence, contradicting the findings of previous studies.
Dr. Rock explained that although genetic and metabolic factors probably influenced the relationship between circulating sex hormones and risk of recurrence, the study indicated that higher concentrations of estradiol in the blood contributed to risk of recurrence.
(Source: Cancer Epidemiology, Biomarkers and Prevention, 2008; 17:614-620.)
(C) 2008 Nutrition Health Review. via ProQuest Information and Learning Company; All Rights Reserved
